Esther, the last of the historical books, contains an early example of Jewish persecution. Esther, a Jewess, is chosen as the new queen for Ahasuerus, the king of Persia. Her uncle Mordecai has incurred the enmity of Haman, the evil court favorite, and so brought the threat of death to his people. Esther, through her position, is able to avert the tragedy and save her people.

Esther 3

3:6 And he thought scorn to lay hands on Mordecai alone; for they had showed him the people of Mordecai: wherefore Haman sought to destroy all the Jews that were throughout the whole kingdom of Ahasuerus, even the people of Mordecai.